Our Latest Research

Since 2007, FRONTIER has been at the forefront of research into frontotemporal dementia (FTD) and related conditions. We have published over 550 peer-reviewed scientific articles, making significant contributions to improving diagnosis, understanding prognosis, and guiding care.

Our work covers a wide range of areas—including cognition, speech and language, behaviour, social functioning, neuroimaging, genetics, and clinical management—shaping current knowledge of FTD and other forms of dementia.

To learn more, visit the Google Scholar profiles of our research leads and explore the breadth and impact of their work.

Below are a few selected publications we’d like to highlight.

Latest Publications

  • Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders

    Brain Commun. 2025 May 22;7(3):fcaf199. doi: 10.1093/braincomms/fcaf199.eCollection 2025.

    de Boer SCM, Riedl L, Braak S, Fenoglio C, Foxe D, et al.

    This publication demonstrates that cognitive screening, letter fluency, and attention assessments are effective tools for differentiating behavioural variant frontotemporal dementia from late-onset primary psychiatric disorders.

    Last updated: September 5th 2025.

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  • Development of the Flexibility in Daily Life scale to measure multidimensional cognitive and behavioural flexibility in health and disease

    Br J Clin Psychol. 2025 Jun;64(2):315-329. doi: 10.1111/bjc.12505.Epub 2024 Sep 22.

    Horne K, Chen T, Irish M.

    This publication introduces and validates the new Flexibility in Daily Life (FIDL) questionnaire, showing it reliably measures thinking and behavior flexibility across different ages.

    Last updated: September 5th 2025.

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  • Interpreting Addenbrooke's Cognitive Examination-III Scores in Dementia: Performance Distributions and Clinically Meaningful Change

    Eur J Neurol. 2025 Jul;32(7):e70257. doi: 10.1111/ene.70257.

    Carrick J, Cheung SC, Foxe D, Piguet O.

    This publication offers practical reference ranges and meaningful yearly change thresholds for the ACE-III cognitive test, helping clinicians better track dementia progression.

    Last updated: September 5th 2025.

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  • Behavioural and cognitive profiles in frontotemporal dementia and Alzheimer's disease: a longitudinal study

    J Neurol. 2025 Mar 21;272(4):279. doi: 10.1007/s00415-025-13025-z.

    Zhang X, Irish M, Piguet O, Ahmed RM.

    This publication tracks how behaviour and thinking abilities change over time in different types of dementia; AD and variants of FTD to help clinicians understand and compare how these conditions progress.

    Last updated: September 5th 2025.

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  • Fourteen years later: Reviewing the diagnostic criteria for behavioral-variant frontotemporal dementia

    Alzheimers Dement. 2025 Jan;21(1):e070604. doi: 10.1002/alz.70604.

    Piguet O, Clarke A. J, Foxe D, Tse N Y, et al.

    This publication examines the diagnostic criteria for behavioral‐variant frontotemporal dementia, highlighting that the cognitive criterion may be overly restrictive and potentially delay diagnosis and treatment.

    Last updated: September 5th 2025.

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  • Survival rates in frontotemporal dementia and Alzheimer’s disease

    J Neurol. 2025 Mar 21;272(4):279. doi: 10.1007/s00415-025-13025-z.

    Foxe D, Muggleton J, Cheung SC, Mueller N, Ahmed RM, et al.

    This publication explores the distinct survival patterns across FTD and AD subtypes. Demographic and presenting clinical features provide valuable prognostic insights for survival.

    Last updated: September 5th 2025.

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  • A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions

    Alzheimer Dement. 2025;11(3):e070184. doi: 10.1002/dad2.70184.

    Ambikairaj A, Foxe D, de Lange A, et al.

    The publication examines the role of digital and remote assessment approaches in enhancing the diagnosis and monitoring of Alzheimer’s disease and related dementias.

    Last updated: September 30th 2025.

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