Our Latest Research

Since 2007, FRONTIER has been at the forefront of research into frontotemporal dementia (FTD) and related conditions. We have published over 550 peer-reviewed scientific articles, making significant contributions to improving diagnosis, understanding prognosis, and guiding care.

Our work covers a wide range of areas—including cognition, speech and language, behaviour, social functioning, neuroimaging, genetics, and clinical management—shaping current knowledge of FTD and other forms of dementia.

To learn more, visit the Google Scholar profiles of our research leads and explore the breadth and impact of their work.

Below are a few selected publications we’d like to highlight.

Latest Publications

  • Modeling contributions of cognition and apathy to functional impairment in younger-onset dementia

    Alzheimers Dement (Amst). 2026 Jan 20;18(1):e70249. doi: 10.1002/dad2.70249.

    PMID: 41573421; PMCID: PMC12819045.

    Warren SL, Ahmed RM, Piguet O, Foxe D, Irish M.

    Last updated: February 18th 2026.

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  • Social cognition in the nonfluent and logopenic variants of primary progressive aphasia: A review of variant-specific profiles

    Cortex. 2025 Dec;193:171-190. doi: 10.1016/j.cortex.2025.10.007. Epub 2025 Nov 5. PMID: 41259904.

    Cordonier N, Piguet O.

    Last updated: February 18th 2026.

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  • Cognitive-linguistic skills in production of expository discourse: Insights from longitudinal changes and neural correlates in primary progressive aphasia

    Cortex. 2026 Jan;194:121-142. doi: 10.1016/j.cortex.2025.11.011. Epub 2025 Dec 1. PMID: 41391212.

    Anwia MA, Lowe MS, Matis S, Carrick J, Piguet O, Landin-Romero R, Ballard KJ.

    Last updated: February 18th 2026.

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  • Glial and neuronal cell-free DNA in plasma of sporadic bvFTD and late onset primary psychiatric disease patients

    Sci Rep. 2025 Nov 6;15(1):38844. doi: 10.1038/s41598-025-22667-y. PMID: 41198751; PMCID: PMC12592525.

    Chatterton Z, de Boer SCM, Riedl L, Matis S, Fenoglio C, Rue I, Landin-Romero R, Southwood D, Galimberti D, Arighi A, Diehl-Schmid J, Ducharme S, Pijnenburg YAL, Piguet O, Halliday G.

    Last updated: February 18th 2026.

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  • Interpreting Addenbrooke's Cognitive Examination-III Scores in Dementia: Performance Distributions and Clinically Meaningful Change

    Eur J Neurol. 2025 Jul;32(7):e70257. doi: 10.1111/ene.70257.

    Carrick J, Cheung SC, Foxe D, Piguet O.

    This publication offers practical reference ranges and meaningful yearly change thresholds for the ACE-III cognitive test, helping clinicians better track dementia progression.

    Last updated: September 5th 2025.

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  • Development of the Flexibility in Daily Life scale to measure multidimensional cognitive and behavioural flexibility in health and disease

    Br J Clin Psychol. 2025 Jun;64(2):315-329. doi: 10.1111/bjc.12505.Epub 2024 Sep 22.

    Horne K, Chen T, Irish M.

    This publication introduces and validates the new Flexibility in Daily Life (FIDL) questionnaire, showing it reliably measures thinking and behavior flexibility across different ages.

    Last updated: September 5th 2025.

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  • Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders

    Brain Commun. 2025 May 22;7(3):fcaf199. doi: 10.1093/braincomms/fcaf199.eCollection 2025.

    de Boer SCM, Riedl L, Braak S, Fenoglio C, Foxe D, et al.

    This publication demonstrates that cognitive screening, letter fluency, and attention assessments are effective tools for differentiating behavioural variant frontotemporal dementia from late-onset primary psychiatric disorders.

    Last updated: September 5th 2025.

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